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Excretion of salicylic acid is dose-dependent, because its metabolism may limit the enzyme system. Half-life is 2-3 hours when applied at low doses of ASA and 15 hours when using the drug in high dose (usual dose of acetylsalicylic acid as an analgesic). Unlike other salicylates, when multiple dose ASA negidrolizirovannaya drug does not accumulate…

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In patients with diabetes, hypoglycemia, hyperthyroidism, chronic obstructive pulmonary disease (COPD), Prinzmetal angina, pheochromocytoma (while the use of alpha-blockers, sm. section “Special Instructions”), occlusive peripheral vascular disease, atrioventricular block I degree , chronic heart failure with reduced myocardial contractility, left ventricular fluoxymesterone halotestin dysfunction after acute myocardial infarction, psoriasis, renal dysfunction, depression, myasthenia gravis, during general…

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Carvedilol is rapidly and almost completely absorbed after oral administration of the gastrointestinal tract. It is almost completely bound to plasma proteins (98-99%). Plasma concentration is proportional to the dose. The bioavailability of approximately 25% due to the high degree of metabolism in the liver. Thus produced metabolites, having a high ability to block beta-adrenoceptors…

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