In patients with diabetes, hypoglycemia, hyperthyroidism, chronic obstructive pulmonary disease (COPD), Prinzmetal angina, pheochromocytoma (while the use of alpha-blockers, sm. section “Special Instructions”), occlusive peripheral vascular disease, atrioventricular block I degree , chronic heart failure with reduced myocardial contractility, left ventricular fluoxymesterone halotestin dysfunction after acute myocardial infarction, psoriasis, renal dysfunction, depression, myasthenia gravis, during general anesthesia, allergic history (see. section “Special instructions”), for the treatment of alpha- blockers and alpha-adrenergic agonists, while the use of cardiac glycosides, diuretics and / or inhibitors of monoamine oxidase (MAO), blockers of the “slow” calcium channel blockers (verapamil, diltiazem).
Application of pregnancy and during breastfeeding
Controlled clinical studies in pregnant women taking carvedilol, have been conducted. Animal studies have revealed the presence of reproductive toxicity, the potential risk for humans is unknown. Beta-blockers reduce placental blood flow, which can lead to fetal death or premature birth. In addition, in the fetus and newborn may develop hypoglycaemia, bradycardia, increased risk of complications in the heart and lungs. The drug is contraindicated during pregnancy, except in cases where the application of benefit to the mother outweighs the potential risk to the fetus. Animal studies have not revealed teratogenic.
It is not known whether carvedilol passes into breast milk, however the majority of beta-blockers lipophilic structures in varying degrees into breast milk.
If necessary, use during lactation breastfeeding should be discontinued.
Dosing and Administration
Carvedilol Sandoz ® is taken orally, drinking plenty of fluids.
Carvedilol is derived mainly through the digestive tract, therefore, in violation of kidney function cumulation of the drug is observed. Hypertension: The initial dose – 12.5 mg / day once (after breakfast) for the first 2 -x days, then 25 mg once daily. If necessary, after 14 days, the dose can be increased. The maximum dose – 50 mg per day in single or 2 divided doses (morning and evening). In older patients, in some cases a dose of 12.5 mg may be effective. Angina: Initial dose – 12 5 mg 2 times a day for the first 2 days, then 25 mg twice (morning and evening) a day. If necessary, after 7-14 days of daily dose may be increased to a maximum of 100 mg / day, divided into 2 doses. In the elderly, the maximum daily dose is 50 mg, divided into 2 doses. Chronic heart failure: Dose picked individually conducting a thorough monitoring. It is necessary to observe the condition of the patient within the first 2-3 hours after the first dose on or after the first dose is increased. The dosage and administration of other drugs, such as digoxin, diuretics and ACE inhibitors should be fixed before the appointment of fluoxymesterone halotestin . Should be taken with food (to reduce the risk of orthostatic hypotension).The recommended starting dose of 3,125 mg twice a day for 14 days. With good tolerability and the need to increase the dosage of drug administered in a dose of 6.25 mg twice a day, and then to 25 mg twice a day. Patients administered the maximum tolerated dose. The maximum recommended dose -. 25 mg twice daily for patients weighing up to 85 kg and 50 mg twice daily for patients weighing more than 85 kg in the early treatment and prior to each increasing dose should monitor the patient’s condition, as . possible worsening of heart failure may develop fluid retention, and due to the presence of a vasodilator effect – hypotension and lethargy. When fluid retention should increase the dose of diuretics, in addition, may require temporary dose reduction fluoxymesterone halotestin . Sometimes a temporary suspension of treatment is required. Acheter steroide, rich piana taille steroide anabolisant.