A highly efficient antianginal drugs from the group of nitrates efficient, reliable and sustained actionusually not observed the development of tolerance to the drugrestore myocardial oxygen balance a wide range of dosages and usability. Low cost halotestin cycle of treatment available to any patient.
Each tablet Kardiket retard 20, 40 or 60 comprising 20, 40 or 60 mg of isosorbide dinitrate prolonged action. Each capsule contains 120 Kardiket retard 120 mg isosorbide dinitrate sustained-release.
- long-term treatment of coronary heart disease
- prevention of angina attacks
- subsequent treatment of myocardial infarction
- pulmonary hypertension
- treatment of chronic congestive heart failure in conjunction with cardiac glycosides and / or diuretics.
MECHANISM OF ACTION:
The action of isosorbide dinitrate is due to relaxation of vascular smooth muscle cells in the veins, arteries and arterioles. Dilation of postcapillary vascular bed leads to venous blood depositary that, in turn, decreases venous return to the heart. As a result, the filling pressure is reduced and left ventricular wall stress is reduced (reduced preload), thereby decreasing the need for myocardial oxygen and energy. Decreased cardiac filling pressure and reduced wall stress contribute to the strengthening of capillary blood flow, and opening previously sealed intramural coronary vessels, as well as improving the supply of oxygen ischemic subendocardial area. Dilation precapillary halotestin cycle vessels leads to a decrease in systolic blood pressure and peripheral vascular resistance (afterload reduction). This reduces the cardiac output from the left ventricle and myocardial oxygen demand. Direct dilatation of the coronary vessels and eccentric coronary stenoses, as well as a slight decrease in their resistance to cause an improvement in myocardial perfusion and supply it with oxygen without the development of “steal syndrome”.
DOSAGE AND ADMINISTRATION:
Dosage depends on the disease stage and individual needs in nitrates. With long-term treatment and the absence of other regulations recommend the following dosage:
- Kardiket retard 20 – 2-3 times 1 tablet a day
- Kardiket retard 40 – 2 times 1 tablet a day
- Kardiket retard 60 – 1 tablet per day or 2 times 1 tablet a day
- Kardiket Retard 120 – 1 capsule per day preferably in the morning
Kardiket take the food with liquid squeezed small amount of liquid. When assigning more than one pill a day, the second can take only 8 hours after the first dose to ensure the full effect of the drug.
Kardiket retard should not be administered in the case of acute myocardial moikarda, as well as in all cases, reduce cardiac filling pressure, acute circulatory failure (shock, circulatory collapse), hypotension (systolic blood pressure below 90 mm Hg).
Early treatment with nitrates may appear headache, which passes in a few days, as well as lowering blood pressure, drowsiness and tachycardia. In some cases, possible nausea, vomiting, and erythema.
Interactions with other drugs:
The antihypertensive effect may be Kardketa retard potentized simultaneous use of other vasodilators, antihypertensive agents, calcium antagonists, cyclic antidepressants, monoamine oxidase inhibitors and alcohol. When concomitant administration halotestin cycle of isosorbide dinitrate and dihydroergotamine, the last level in the blood can increase, leading to a strengthening of its hypotensive action.
- Kardiket not suitable for the treatment of acute attacks of angina treatment.
- The drug should not be taken in the first three months of pregnancy without a doctor’s recommendation.