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Excretion of salicylic acid is dose-dependent, because its metabolism may limit the enzyme system. Half-life is 2-3 hours when applied at low doses of ASA and 15 hours when using the drug in high dose (usual dose of acetylsalicylic acid as an analgesic). Unlike other salicylates, when multiple dose ASA negidrolizirovannaya drug does not accumulate…

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Carboplatin is excreted mainly by the kidneys, and about 30% of the administered dose is excreted unchanged. In patients with a creatinine clearance of 60 ml / min or more, about 65% and 70% of the administered dose was excreted respectively for 12 and 24 hours after administration. Since carboplatin appears almost entirely by glomerular…

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